In conclusion, peptides W Q and T, which are HERV-W env antigenic epitopes, have both antigenicity and immunogenicity, and can cause strong T cell immune responses. These data demonstrate that human T cells can be sensitized toward HERV-W env peptides ( W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. Besides lysis of HERV-W env-loaded target cells, specific apoptosis was also observed. High numbers of IFN-γ-secreting T cells were also detectable after several weekly stimulations with W, Q and T.
Stimulation of peripheral blood mononuclear cells from HLA-A*0201 + donors with each of these peptides induced peptide-specific CD8 + T cells. A CCK-8 assay showed peptides W, Q and T promoted lymphocyte proliferation. Five peptides displaying HLA-A*0201-binding motifs were predicted using SYFEPITHI and BIMAS, and synthesized.
In the present study, HERV-W env-derived epitopes presented by HLA-A*0201 are described with the potential for use in adoptive immunotherapy. However, there are no reports investigating whether human leukemia antigen (HLA)-A*0201 + restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. Human endogenous retrovirus W family ( HERV-W) envelope (env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity. Tu, Xiaoning Li, Shan Zhao, Lijuan Xiao, Ran Wang, Xiuling Zhu, Fan These creations are available under CreativeĬommons Attribution 3.0 United States license.Human leukemia antigen-A*0201-restricted epitopes of human endogenous retrovirus W family envelope ( HERV-W env) induce strong cytotoxic T lymphocyte responses. The 25 following 3D models were created by ReallusionĪnd distributed here with their authorization. Of 3D models contained in the 3DModels-BlendSwap-CC-0-1.8.zip The set of Blend Swap models is available as the BlendSwap-CC-0.sh3f and BlendSwap-CC-BY.sh3f libraries The 395 following 3D models were created by the author of Resources.blogscopia and are available under CreativeĬommons Attribution 3.0 Unported license, with the requirement of giving credit only in case a 3D model or a work derived from it is redistributed (see Scopia license). Of 3D models contained in the 3DModels-Contributions-1.8.zip The set of previous models is available as the Contributions.sh3f, LucaPresidente.sh3f and Trees.sh3f libraries Trees were modeled with Arbaro to generate their branches and foliage, then simplified to reduce their size. The creator of each 3D model is indicated when you place the mouse pointer on its image. The 580 following 3D models were created by contributors of Sweet Home 3D project, and are available under To import the 3D models libraries that gather the objects of this page.ģD models created by Sweet Home 3D contributors Unless you need to adjust the orientation and other parameters of a model, it's faster and easier Sweet Home 3D lets you import 3D models one by one, or by group
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